Treatment of vascular problems of the skin and subcutaneous tissue is a major area of dermatological therapy given the increasingly large aging population. A number of dermatological conditions which involve blood vessel disorders of the skin and skin disorders caused by photoaging include actinic and iatrogenic purpura, lentigines, telangiectasias of the face, spider angiomas, spider veins of the face, spider veins of the legs as well as other vascular problems of the skin and subcutaneous tissue. There is currently no treatment for actinic or iatrogenic purpura and the only treatment for spider veins is surgical. Thus, treatments for these various blood vessel disorders of the skin are clearly limited at best.